Video: WLWT News 5. Watch on WLWT’s YouTube channel.
GLP-1 medications have brought new attention to the relationship between metabolic health and fertility. For someone taking medication for weight management or diabetes, changes in menstrual cycles and the possibility of pregnancy deserve a conversation early in treatment.
On November 11, 2026, Dr. Jon E. Mendelsohn and nurse practitioner Donna Abdenour joined WLWT News 5 to discuss this important topic.
Watch the interview and read WLWT’s coverage.
Why might fertility change?
Metabolic health and reproductive health are connected. In some people, obesity and insulin resistance can interfere with regular ovulation. This is particularly relevant for people with polycystic ovary syndrome, or PCOS.
When treatment improves metabolic health and supports weight loss, ovulation may become more regular. Pregnancy can therefore become possible even for someone who has previously experienced irregular cycles or difficulty conceiving.
That does not make GLP-1 medications fertility treatments, and improved fertility is not guaranteed. Age, underlying conditions and other factors still matter. The practical takeaway is to discuss pregnancy intentions with your clinician rather than assume that a history of infertility means contraception is unnecessary.
Are semaglutide and tirzepatide the same?
They act on related pathways, but they are different medications.
- Semaglutide, the medicine in Ozempic and Wegovy, activates the GLP-1 receptor.
- Tirzepatide, the medicine in Mounjaro and Zepbound, activates both GIP and GLP-1 receptors.
Their instructions are not interchangeable. The exact product, why it was prescribed and your health history determine the advice that applies to you.
What should you know about birth control?
Tirzepatide can affect the absorption of oral hormonal contraceptives. Its prescribing information advises switching to a non-oral contraceptive method or adding a barrier method for four weeks after starting treatment and for four weeks after each dose increase.
This is a specific medication consideration, not a blanket statement that all GLP-1 medicines make every type of contraception less effective. Ask your prescriber which precautions apply to your medication and contraceptive method.
What if you are planning pregnancy?
Discuss your timeline before trying to conceive. Weight-loss treatment is not appropriate during pregnancy, and medication planning may need to begin well before conception.
For example, Wegovy’s prescribing information advises stopping it at least two months before a planned pregnancy when used for weight reduction. Other medications require their own plan.
If pregnancy occurs during treatment, promptly contact your prescriber and obstetric clinician. If you are being treated for diabetes, make sure you also have a plan to maintain appropriate blood-sugar control.
Questions to bring to your appointment
- Could my metabolic health be affecting my menstrual cycles or ovulation?
- Does my medication affect my birth control?
- How far ahead should we adjust treatment if I want to become pregnant?
- Who will coordinate my medication and pregnancy care?
At Advanced Cosmetic Surgery & Laser Center, our Vitality Services conversations begin with your health history and goals. Pregnancy planning should be coordinated with your prescribing clinician and obstetric or fertility care team.
This article provides general education and does not replace individualized medical advice.
